| 04/12/2021 | White Sox | Reds | 5:00PM - 6:30PM | George Sim Park / Matt Cain Field / Matt Cain (Field 1) | |
| 04/16/2021 | Orioles | Red Sox | 5:00PM - 6:30PM | George Sim Park / Matt Cain Field / Matt Cain (Field 1) | |
| 04/17/2021 | White Sox | Dodgers | 11:30AM - 1:30PM | Phoebe Hearst / Phoebe Hearst Field 2 | |
| 04/17/2021 | Orioles | Reds | 1:45PM - 3:45PM | Phoebe Hearst / Phoebe Hearst Field 2 | |
| 04/19/2021 | White Sox | Red Sox | 5:00PM - 7:00PM | Phoebe Hearst / Phoebe Hearst Field 2 | |
| 04/24/2021 | Dodgers | Orioles | 9:00AM - 11:00AM | Phoebe Hearst / Phoebe Hearst Field 1 | |
| 04/24/2021 | Red Sox | Reds | 2:15PM - 4:15PM | Phoebe Hearst / Phoebe Hearst Field 2 | |
| 04/26/2021 | Reds | Dodgers | 5:00PM - 7:00PM | Phoebe Hearst / Phoebe Hearst Field 1 | |
| 05/01/2021 | Orioles | Red Sox | 9:00AM - 11:00AM | Phoebe Hearst / Phoebe Hearst Field 1 | |
| 05/01/2021 | Reds | Dodgers | 11:15AM - 1:15PM | Phoebe Hearst / Phoebe Hearst Field 1 | |
| 05/03/2021 | White Sox | Orioles | 5:00PM - 7:00PM | Phoebe Hearst / Phoebe Hearst Field 2 | |
| 05/08/2021 | Dodgers | Red Sox | 11:30AM - 1:30PM | Phoebe Hearst / Phoebe Hearst Field 2 | |
| 05/08/2021 | White Sox | Reds | 11:30AM - 1:30PM | Phoebe Hearst / Phoebe Hearst Field 1 | |
| 05/10/2021 | Reds | Orioles | 5:00PM - 7:00PM | Phoebe Hearst / Phoebe Hearst Field 1 | |
| 05/15/2021 | Red Sox | White Sox | 9:00AM - 11:00AM | Phoebe Hearst / Phoebe Hearst Field 1 | |
| 05/15/2021 | Dodgers | Orioles | 11:15AM - 1:15PM | Phoebe Hearst / Phoebe Hearst Field 1 | |
| 05/17/2021 | Reds | Red Sox | 5:00PM - 7:00PM | Phoebe Hearst / Phoebe Hearst Field 1 | |
| 05/22/2021 | White Sox | Dodgers | 9:00AM - 11:00AM | Phoebe Hearst / Phoebe Hearst Field 1 | |
| 05/22/2021 | Red Sox | Orioles | 11:15AM - 1:15PM | Phoebe Hearst / Phoebe Hearst Field 1 | |
| 05/24/2021 | Reds | White Sox | 5:00PM - 7:00PM | Phoebe Hearst / Phoebe Hearst Field 1 | |
| 06/05/2021 | Orioles | Red Sox | 11:30AM - 1:30PM | Phoebe Hearst / Phoebe Hearst Field 2 | |
| 06/05/2021 | Reds | Dodgers | 2:30PM - 4:30PM | Phoebe Hearst / Phoebe Hearst Field 3 | Rescheduled |
| 06/07/2021 | Dodgers | White Sox | 5:00PM - 7:00PM | Phoebe Hearst / Phoebe Hearst Field 1 | |